Evaluation of Pharmacodynamic Properties and Safety of Cinnamomum Zeylanicum (Ceylon Cinnamon) in Health Adults: Study Protocol for a Phase I Clinical Trial
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چکیده
Submit Manuscript | http://medcraveonline.com Abbreviations: ALD: Alcoholic Liver Disease; FBG: Fasting Blood Glucose; LDL: Low Density Lipoprotein; HDL: High Density Lipoprotein; VAS: Visual Analog Scales; FBC: Full Blood Count; SBP: Systolic Blood Pressure; DBP: Diastolic Blood Pressure; BMI: Body Mass Index; WC: Waist Circumference; HC: Hip Circumference; WHR: Waist Hip Ratio; FFQ: Food Frequency Questionnaire; CRF: Case Record Form; ALT: Alanine Aminotransferase; AST: Aspartate aminotransferase; HOMA-IR: Homeostasis Model of Assessment-Insulin Resistance; CRF: Case report form; SOP: Standard Operating Procedure; CRA: Clinical Research Associate; SPSS: Statistical Package For The Social Sciences; WHO: World Health Organization; AUC: Area Under The Curve
منابع مشابه
Evaluation of pharmacodynamic properties and safety of Cinnamomum zeylanicum (Ceylon cinnamon) in healthy adults: a phase I clinical trial
BACKGROUND Cinnamon is considered as a treatment for many ailments in native medicine. Evidence suggests that Cinnamomum zeylanicum (CZ) has anti-microbial, anti-parasitic, anti-oxidant, blood glucose lowering properties and beneficial cardiovascular effects. The present study aims to evaluate Pharmacodynamic properties and safety of CZ in healthy adults using a Phase I Clinical Trial. METHOD...
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BACKGROUND Previous studies have explored the anti-diabetic effects of Cinnamomum cassia extract in vivo and in vitro. However, there are no studies at present exploring the effects of the indigenous species of Sri Lankan cinnamon (Cinnamomum zeylanicum) in patients with diabetes mellitus. The present study aims to evaluate the potential effects of Cinnamomum zeylanicum extract as a pharmaceuti...
متن کاملCinnamon (Cinnamomum spp.)
American cinnamon, Batavia cassia, Batavia cinnamon, breyne, cannelle (French), cannellier de Ceylan (French), cannellier de Chine (French), cassia, cassia bark, cassia cinnamon, cassia lignea, cassia rou gui, catechins, Ceylon cinnamon, Chinese cinnamon, chinesischer Zimt (German), chinesischer Zimtbaum (German), cinnamaldehyde, cinnamate, cinnamic acid, cinnamom--dhal chini, Cinnamomi cassiae...
متن کاملEffects of Cinnamomum zeylanicum (Ceylon cinnamon) on blood glucose and lipids in a diabetic and healthy rat model
OBJECTIVES To evaluate short- and long-term effects of Cinnamomum zeylanicum on food consumption, body weight, glycemic control, and lipids in healthy and diabetes-induced rats. MATERIALS AND METHODS The study was conducted in two phases (Phase I and Phase II), using Sprague-Dawley rats in four groups. Phase I evaluated acute effects on fasting blood glucose (FBG) (Groups 1 and 2) and on post...
متن کاملMedicinal properties of ‘true’ cinnamon (Cinnamomum zeylanicum): a systematic review
BACKGROUND In traditional medicine Cinnamon is considered a remedy for respiratory, digestive and gynaecological ailments. In-vitro and in-vivo studies from different parts of the world have demonstrated numerous beneficial medicinal effects of Cinnamomum zeylanicum (CZ). This paper aims to systematically review the scientific literature and provide a comprehensive summary on the potential medi...
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